Werner Tjarks Selected Research

Thymidine

12/2015	Evaluation of TK1 targeting carboranyl thymidine analogs as potential delivery agents for neutron capture therapy of brain tumors.
4/2013	N3-substituted thymidine bioconjugates for cancer therapy and imaging.
9/2012	Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors.
11/2008	Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors.
3/2008	Synthesis and biological evaluation of inhibitors of thymidine monophosphate kinase from Bacillus anthracis.
10/2006	Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer.
9/2006	Preparation and biological evaluation of 10B-enriched 3-[5-{2-(2,3-dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl]thymidine (N5-2OH), a new boron delivery agent for boron neutron capture therapy of brain tumors.
2/2005	Synthesis and biological evaluation of neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy.
9/2004	Evaluation of human thymidine kinase 1 substrates as new candidates for boron neutron capture therapy.
9/2004	Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.

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Werner Tjarks Research Topics

Disease

27	Neoplasms (Cancer) 12/2015 - 03/2002
15	Glioma (Gliomas) 12/2015 - 06/2002
10	Brain Neoplasms (Brain Tumor) 12/2015 - 01/2004
2	Anthrax 03/2008 - 12/2006
1	Breast Neoplasms (Breast Cancer) 09/2005
1	Melanoma (Melanoma, Malignant) 09/2004
1	Carcinoma (Carcinomatosis) 07/2003
1	Sarcoma (Soft Tissue Sarcoma) 01/2003
1	Mouth Neoplasms (Oral Cancer) 08/2002

Drug/Important Bio-Agent (IBA)

17	BoronIBA 04/2013 - 03/2002
11	ThymidineIBA 12/2015 - 08/2002
7	thymidine kinase 1IBA 12/2015 - 09/2004
6	Epidermal Growth Factor (EGF)IBA 12/2009 - 06/2002
6	ErbB Receptors (EGF Receptor)IBA 02/2008 - 06/2002
6	Liposomes (Liposome)IBA 01/2007 - 05/2002
5	Dendrimers (Dendrons)IBA 12/2009 - 11/2002
5	Cetuximab (Erbitux)FDA Link 02/2008 - 01/2004
5	Folic Acid (Vitamin M)FDA LinkGeneric 07/2003 - 05/2002
4	Monoclonal AntibodiesIBA 02/2008 - 11/2004
3	EnzymesIBA 12/2015 - 09/2004
3	NucleosidesIBA 07/2015 - 09/2004
3	epidermal growth factor receptor VIIIIBA 02/2008 - 01/2004
2	Biological ProductsIBA 09/2006 - 02/2005
1	pyrimidineIBA 07/2015
1	Thymidine KinaseIBA 07/2015
1	EstersIBA 09/2012
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 09/2012
1	ProdrugsIBA 09/2012
1	Amino Acids FDA Link 09/2012
1	Glutamic Acid (Glutamate)FDA Link 09/2012
1	Valine (L-Valine)FDA Link 09/2012
1	A 7 (A-7)IBA 12/2009
1	dTMP kinaseIBA 03/2008
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2008
1	Phosphates (Orthophosphate)IBA 03/2008
1	Thymidine Monophosphate (TMP)IBA 03/2008
1	dodecaborateIBA 01/2007
1	AnionsIBA 01/2007
1	Boron CompoundsIBA 01/2007
1	CholesterolIBA 01/2007
1	Biological Warfare AgentsIBA 12/2006
1	cyanine dye 5IBA 09/2005
1	Proteins (Proteins, Gene)FDA Link 09/2005
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2005
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 09/2005
1	Nucleic Acid PrecursorsIBA 09/2004
1	Boron-10IBA 09/2004
1	Ethylene Glycol (Monoethylene Glycol)IBA 01/2003
1	Poly(amidoamine)IBA 01/2003
1	CytosineIBA 08/2002
1	Sulfides (Thioethers)IBA 03/2002

Therapy/Procedure

21	Boron Neutron Capture Therapy 07/2015 - 03/2002
12	Neutron Capture Therapy 12/2015 - 06/2002
4	Therapeutics 04/2013 - 03/2002
1	Radiotherapy 01/2012
1	Injections 11/2008
1	Nuclear Reactors 02/2008